Research Team
for Cellular

The Team


Domenik Liße (Dr. Dipl. Ing. (FH))
Team Leader

Annette Budke-Gieseking
Lab Management & Technical Assistence

Marie Kappen (M. Sc.)
PhD Student



  • Genetical & Chemical Protein Engineering and Protein Production
  • Design & Synthesis of Fluorescent and Magnetic Nanobiomaterials
  • Design & Synthesis of Small Bioactive Organic Ligands
  • Quantitative & Qualitative Fluorescence Microscopy
  • Development & Establishment of Cellular Approaches
  • Intracellular Application of Functionalized Nanoparticles

Selected Publications

Surface protein engineering increases circulation time of cell membrane-based Nanotherapeutic
S. Krishnamurthy, P. Muthukumaran, M.K.G. Jayakumar, D. Lisse, N.D. Masurkar, C. Xu, J.M. Chan, C.L. Drum, (2019) Nanomedicine 19, 30057-7

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells
F. Etoc, E. Balloul, C. Vicario, D. Normanno, D. Liße, A. Sittner, J. Piehler, M. Dahan & M. Coppey, (2018) Nature Materials 17, 740–746

Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells
D.Liße*, C. Monzel*, A. Egron, C. Vicario, J. Piehler, M. Coppey, M. Dahan, (2017) Advanced Materials 29

Magnetogenetic Control of Protein Gradients Inside Living Cells with High Spatial and Temporal Resolution
F. Etoc*, C. Vicario*, D. Liße*, Jean-Michel Siaugue, J. Piehler, M. Coppey, M. Dahan, (2015) Nano Letters 15(5), 3487-94

Monofuctional Stealth Nanoparticles for Unbiased Single Molecule Tracking Inside Living cells
D. Liße, C. P. Richter, C. Drees, O. Birkholz, C. You, E. Rampazzo, J. Piehler; (2014) Nano Letters 14(4), 2189-95

Subcellular control of Rac-GTPase Signalling by Magnetogenetic Manipulation Inside Living Cells
F. Etoc, D. Liße, Y. Bellaiche, J. Piehler, M. Coppey, M. Dahan; (2013) Nature Nanotechnology 8, 193-198

Selective Targeting of Fluorescent Nanoparticles to Proteins Inside Living Cells
D. Liße, V. Wilkens, C. P. Richter, K. Busch, J. Piehler; (2011) Angewandte Chemie Int. Ed. 50, 9352-9355

Research Team for Cellular Nanobiotechnology

University of Osnabrück
Department of Biology/Chemistry
Division of Biophysics & CellNanOs
Barbarastraße 11, Building 38
49076 Osnabrück, Germany
+49 541 969 7345

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