Names in bold indicate contributions from our laboratory


     Jürgens, K.J., Drechsler, M. and Paululat, A. (submitted) The Anatomy of Drosophila melanogaster - the wild-type: A collection of scanning electron microscopy images for students and researchers.

     Bucher, G., Fischer, K., Gerlach, G., Harzsch, S., Merzendorfer, H., Paululat, A., Reinhold, K., Rödel, M.-O., Röder, T., Schmidt-Rhaesa, A., Schneider, J., Steffan-Dewenter, I., & Uhl, G. (2023). Publizieren in einem sich wandelnden Umfeld. Biologie in Unserer Zeit, 53(4), 311–312. (download german version) (download english translation)

     Paululat, A. und Purschke, G. (2023) Metazoa - Morphologie und Evolution der vielzelligen Tiere. Ein Praxisbuch zum zoologischen Praktikum. 1. Auflage. Springer Spektrum Verlag. (Springer-Link)

     Meyer, C., Drechsler, M., Meyer, H. and Paululat, A. (2023) Differentiation and function of cardiac valves in the adult Drosophila heart. Journal of Experimental Biology (J Exp Biol) 226(13) doi: 10.1242/jeb.245839.

     Borchers A.-C., Janz, M., Schäfer, J.-H., Moeller, A., Kümmel, D., Paululat, A., Ungermann, C. and Langemeyer, L. (2023) Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation. Proc. Natl. Acad. Sci USA. 120(30): doi: 10.1073/pnas.2303750120.

     Reinhardt, M., Drechsler, M. and Paululat, A. (2023) Drosophila collagens in specialised extracellular matrices. Biological Chemistry. doi: 10.1515/hsz-2022-0297

     Meyer, C., Bataille, L., Drechsler, M. and Paululat, A. (2023) Tailup expression in Drosophila larval and adult cardiac valve cells. Genesis. The Journal of Genetics and Development. e23506: doi: 10.1002/dvg.23506



      Meyer, C., Breitsprecher, L., Bataille, L., Vincent, A.J.M., Drechsler, M., Meyer, H. and  Paululat, A. (2022) Formation and function of a highly specialised type of organelle in cardiac valve cells. Development. 149(19):dev200701. doi: 10.1242/dev.200701.

     Klinke, N., Meyer, H., Ratnavadivel, S., Reinhardt, M., Heinisch, J.J., Malmendal, A., Milting, H. and Paululat, A. (2022) A Drosophila melanogaster model for TMEM43 related Arrhythmogenic right ventricular cardiomyopathy type 5. Cellular and Molecular Life Sciences (Cell Mol Life Sci), 79(8):444. DOI: 10.1007/s00018-022-04458-0

     Schiemann, R., Buhr, A., Cordes, E., Walter, S., Heinisch, J.J., Ferrero, P., Milting, H., Paululat, A. and Meyer, H. (2022) Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides. Nature Communications. 13(1): 4420. DOI: 10.1038/s41467-022-31974-1

     Psathaki, O.-E. and Paululat, A. (2022) Preparation of Drosophila tissues and organs for transmission electron microscopy. Methods in Molecular Biology (Methods Mol Biol). 2540:361-385. doi: 10.1007/978-1-0716-2541-5_19

     Paradis, M., Kucharowski, N., Edwards Farat, G., Palacios, S.J.M., Meyer, C., Stümpes, B., Jamitzky, I., Kalinoswski, J., Thiele, C., Bauer, R., Paululat, A., Sellin, J. and Bülow, M. (2022) The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex activity. Science Advances 8(29):eabo0155. doi: 10.1126/sciadv.abo0155.

     Santalla, M., Garcia, A., Mattiazzi, A., Valverde, C.A., Schiemann, R., Paululat, A., Hernandez, G., Meyer, H. and Ferrero, P. (2022) Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart. PlosOne 17(5). doi: 10.1371/journal.pone.0267156.

     Tögel, M., Pass, G. and Paululat, A. (2022) Wing hearts in four-winged Ultrabithorax-mutant flies - the role of Hox genes in wing heart specification. Genetics. Nov 15:iyab191. doi: 10.1093/genetics/iyab191


     Musielak, M., Sterk, C., Schubert, F., Meyer, C., Paululat, A. and Heinisch, J.J. (2021) The small GTPase KlRho5 responds to oxidative stress and affects cytokinesis in the dairy yeast Kluyveromyces lactis. Journal of Cell Science (JCS). 134(18). jcs258301. doi: 10.1242/jcs.258301

     Vittadello, L., Kijatkin, C., Klenen, J., Dzikonski, D., Kömpe, K., Meyer, C., Paululat, A. and Imlau, M. (2021) In-vivo tracking of harmonic nanoparticles: a study based on a TIGER widefield microscope. Optical Materials Express (OME) 11 (7) 1953-1969.


Dehnen, L.*, Janz, M.*, Kumar Vermar, J., Psathaki, O.E., Langemeyer, L., Fröhlich, F., Heinisch, J.J., Meyer, H., Ungermann, C. and Paululat, A. (2020) A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Journal of Cell Science 133 (13): jcs.247080, doi: 10.1242/jcs.247080.

     Beyenbach, K.W., Schöne, F., Breitsprecher, L.H., Tirbucy, F., Furuse, M., Izumi, Y., Meyer, H., Jonusaite, S., Rodan, A.R. and Paululat, A. (2020) The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. American Journal of Physiology - Cell Physiology. 318 (6): C1107-C1122, doi: 10.1152/ajpcell.00061.2020.

     Bataillé, L., Colombié, N., Pelletier, A., Paululat, A., Lebreton, G., Carrier , Y., Frendo, J.-L. and Vincent, A. (2020) Alary Muscles and TARMs, a novel type of striated muscles maintaining internal organs positions. Development 147 (8). doi: 10.1242/dev.185645. [Epub ahead of print].

     Jonusaite, S., Beyenbach, K.W., Meyer, H., Paululat, A., Izumi. Y., Furuse, M. and Rodan, A.R. (2020) The septate junction protein Mesh is required for epithelial morphogenesis, ion transport and paracellular permeability in the Drosophila Malpighian tubule. American Journal of Physiology - Cell Physiology 318 (3): C675-C694. doi: 10.1152/ajpcell.00492.2019.


          Schiemann, R., Lammers, K., Janz, M., Lohmann, J., Paululat, A. and Meyer, H. (2019) Identification and in vivo characterization of cardioactive peptides in Drosophila melanogaster. International Journal of Molecular Sciences (Int. J. Mol. Sci.) 20, 2 doi:10.3390/ijms20010002.

         Paululat, A. & Heinisch, J. (Eds. of the german edition) (2019) Campbell Biologie. 11. German Edition. Authors: Urry, Cain, Wassermann, Minorsky, Reece, Campbell Biology. Pearson Deutschland GmbH. ISBN 978-3-86894-366-5.


        Drechsler, M., Meyer, H., Wilmes, A. and Paululat, A. (2018) APC/CFzr regulates cardiac and myoblast cell numbers and plays a crucial role during myoblast fusion. Journal of Cell Science (JCS) 131(14), pii: jcs209155, doi: 10.1242/jcs.209155. This article is featured in the “Research Highlight” section of JCS.

        Balcazar, D., Regge, V., Santalla, M., Meyer, H., Paululat, A., Mattiazzi, A. and Ferrero, P. (2018) SERCA is critical to control the Bowditch effect in the heart. Scientific Reports 8:12447. doi:10.1038/s41598-018-30638-9.

        Rotstein, B.*, Post, Y.*, Reinhardt, M., Lammers, K., Buhr, A., Heinisch, J.J., Meyer, H. and Paululat, A. (2018) Distinct domains present in the matricellular protein protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function in Drosophila melanogaster. Journal of Biological Chemistry (JBC) 293 (20): 7864-7879.

        Post, Y. and Paululat, A. (2018) Muscle function assessment using a Drosophila larvae crawling assay. Bio-Protocols 8(14): e2933. doi: 10.21769/BioProtoc.2933.

        Post, Y. and Paululat, A. (2018) Commentary: Distinct Domains in the Matricellular Protein, Lonely Heart, are Crucial for Cardiac Extracellular Matrix Formation and Heart Function in Drosophila. Journal of Cardiology and Cardiovascular Science 2 (5): 1-5.

        Wilmes, A.C., Klinke, N., Rotstein, B., Meyer, H. and Paululat, A. (2018) Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Biology Open 7 (4).  

        Psathaki, E.O., Dehnen, L., Hartley, PS. and Paululat, A. (2018) Drosophila pericardial nephrocyte ultrastructure changes during ageing. Mechanisms of Ageing and Development (MAD) 173: 9-20.    


         Wingen, A.*, Carrera, P.*, Psathaki, O.E., Voelzmann, A., Paululat, A. and Hoch, M. (2017) Debris buster is a Drosophila scavenger receptor essential for airway physiology. Developmental Biology 430: 52-68.

         Lammers, K.*, Abeln, B.*, Hüsken, M.*, Lehmacher, C., Psathaki, O.E., Alcorta, E., Meyer, H. and Paululat, A. (2017) Formation and function of intracardiac valve cells in the Drosophila heart. Journal of Experimental Biology (JEB) 220 (10): 1852-1863.

         Sellin, J., Schulze, H., Paradis, M., Gosejacob, D., Papan, C., Shevchenko, A., Psathaki, O.E., Paululat, A., Thielisch, M., Sandhoff, K. and Hoch, M. (2017) Characterization of Drosophila saposin-related mutants as a model for lysosomal shingolipid storage diseases. Disease Models & Mechanisms (DMM) 10 (6): 737-750.

         Thiel, D., Hugenschütt, M., Meyer, H., Paululat, A., Quijada-Rodriguez, A., Purschke, G. and Weihrauch, D. (2017) Ammonia excretion in the marine polychaete Eurythoe complanata (Annelida) Journal of Experimental Biology 220: 425-436.


         Hallier, B.*, Schiemann, R.*, Cordes, E., Vitos-Faleato, J., Walter, S., Heinisch, J.J., Malmendal, A., Paululat, A. and Meyer, H. (2016) Neprilysins control insulin signaling and food uptake via cleavage of regulatory peptides. eLIFE 2016,5:e19430

         Rotstein, B. and Paululat A. (2016) On the morphology of the Drosophila heart. Journal of Cardiovascular Development and Disease (JCDD) 3, 15: 1-13.

     Ivy, J.R.*, Drechsler, M.*, Catterson, J.H.*, Bodmer, R., Ocorr, K., Paululat, A. and Hartley, P. (2015) Klf15 is critical for the development and differentiation of Drosophila nephrocytes. PLoS One 10(8): e134620.

         Pass, G., Tögel, M., Krenn, H. and Paululat, A. (2015) The circulatory organs of insect wings: prime examples for the origin of evolutionary novelties. Zoologischer Anzeiger 256: 82-95.

        Hallier, B., Hoffmann, J., Roeder, T., Tögel, M., Meyer, H. and Paululat, A. (2015) The bHLH transcription factor Hand regulates the expression of genes critical to heart and muscle function in Drosophila melanogaster. PLoS One 10(8): e0134204.

         Bohnekamp, J., Cryderman, D.E., Paululat, A., Baccam, G., Wallrath, L.L. and Magin, T.M. (2015) A Drosophila model of Epidermolysis Bullosa Simplex. Journal of Investigative Dermatology (JID) 135(8): 20131-2039.    

         Hüsken, M., Hufnagel, K., Mende, K., Appel, E, Meyer, H., Peisker, H, Tögel, M, Wang, S., Wolff, J., Gorb, S.N. and Paululat, A. (2015) Adhesive pad differentiation in Drosophila melanogaster depends on the Polycomb group gene Su(z)2. Journal of Experimental Biology 218: 1159-1165.

         Heinisch, J. & Paululat, A. (Eds. of the german edition) (2015) Campbell Biologie. 10. German Edition. Authors: Reece, Urry, Cain, Wassermann, Minorsky, Jackson Campbell Biology. Pearson Deutschland GmbH. ISBN 3868942599

     Volk, T., Wang, S., Rotstein, B. and Paululat, A. (2014) Matricellular proteins in development: Perspectives from the Drosophila heart. Matrix Biology 37C: 162-166.

         Moschner, K.*, Sündermann, F.*, Meyer, H., da Graca, A.P., Appel, N., Paululat, A., Bakota, L. and Brandt, R. (2014) RNA-protein granules modulate tau isoform expression and induce neuronal sprouting. Journal of Biological Chemistry 289 (24): 16814-16825.

         Rosemeyer, H., Paululat, A. and Heinisch, J.J. (2014) „Yeast mail“: A novel Saccharomyces application (NSA) to encrypt messages. Chemistry & Biodiversity 11(9): 1364-1373.

     Drechsler, M., Schmidt, A., Meyer, H. and Paululat, A. (2013) The conserved ADAMTS-like protein Lonely heart mediates matrix formation and cardiac tissue integrity. PLOS Genetics 9(7): e1003616.

         Tögel, M., Meyer, H., Heinisch, J.J., Lehmacher, C., Pass, G. and Paululat, A. (2013) The bHLH transcription factor Hand is required for proper wing heart formation in Drosophila. Developmental Biology 381(2): 446-459.

         Tögel, M., Pass, G. and Paululat, A. (2013) In vivo imaging of Drosophila wing heart development during pupal stages. International Journal of Developmental Biology 57: 13-24.

         Brandt, R. and Paululat, A. (2013) Microcompartments in the Drosophila heart and the mammalian brain: general features and common principles. Biological Chemistry 394(2): 217-230.

     Paululat, A. and Heinisch, J.J.H. (2012) New Yeast/E.coli/Drosophila triple shuttle vectors for efficient generation of Drosophila P-element transformation constructs. Gene 511(2): 300-305.

         Lehmacher, C., Abeln, B. and Paululat, A. (2012) The ultrastructure of Drosophila heart cells. Arthropod Structure and Development 41: 459-474.

         Panz, M. , Vitos-Faleato, J.V., Jendretzki, A., Heinisch, J., Paululat, A. and Meyer, H. (2012) A novel role for the non catalytic intracellular domain of Neprilysins in muscle physiology. Biology of the Cell 104: 1-16.

         Wang, S., Meyer, H., Ochoa-Espinosa, A., Buchwald, U., Önel, S., Altenhein, B., Heinisch, J., Affolter, M. and Paululat, A. (2012) GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. Journal of Cell Science 125: 461-472.

     Albrecht, S., Altenhein, B., Paululat, A. (2011) The transmembrane receptor Unc5 is essential for cardiac tube alignment and lumen formation in Drosophila. Developmental Biology 350: 89-100.

         Meyer, H., Panz, M., Albrecht, S., Drechsler, M., Wang, S., Hüsken, M., Lehmacher, C. and Paululat, A. (2011) Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. European Journal of Cell Biology 90 (9): 770-778.

         Paululat, A. & Purschke, G. (2011) Wörterbuch der Zoologie. 519 pages, Spektrum Akademischer Verlag, Heidelberg. 8. Auflage

     Meyer, H., von Ohlen, T. , Panz, M. and Paululat, A. (2010) The disintegrin and metalloprotease Meltrin from Drosophila forms oligomers via its protein binding domain and is regulated by the homeobox protein VND during embryonic development. Insect Biochemistry and Molecular Biology 40 (11): 814-823.

         Tögel, M., Pass, G. and Paululat, A. (2010) Herzen beflügeln Fliegen. BioSpektrum 5: 516-519.

     Meyer, H. Panz, M., Zmojdzian, M., Jagla, K. and Paululat, A. (2009) Neprilysin 4, a novel endopeptidase from Drosophila melanogaster displays distinct substrate specificities and exceptional solubility states. Journal of Experimental Biology 212: 3673-3683.    

         Sellin, J.*, Drechsler, M.*, Nguyen, H. and Paululat, A. (2009) Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster. Developmental Biology 326: 444-455.

         Lehmacher, C.*, Tögel, M.*, Pass, G. and Paululat, A. (2009) The Drosophila wing hearts consist of syncytial muscle cells that resemble adult somatic muscles. Arthropod Structure & Development 38: 111-123.

         Hunnekuhl, V., Bergter, A., Purschke, G. and Paululat, A. (2009) Development and embryonic pattern of body wall musculature in the crassiclitellate Eisenia andrei (Annelida, Clitellata) Journal of Morphology 270: 1122-1136

         Tögel, M., Pass, G. and Paululat, A. (2008) The Drosophila wing hearts originate from pericardial cells and are essential for wing maturation. Developmental Biology 318: 29-37.

         Bergter, A., Brubacher, J. and Paululat, A. (2008) Muscle formation during embryogenesis of the polychaete Ophryotrocha diadema (Dorvilleidae) - new insights into annelid muscle patterns. Frontiers in Zoology 5: 1 (p. 1-18).

         Johnson, A.N., Burnett, L.A., Sellin, J., Paululat, A., Newfeld, S.J. (2007) Defective Dpp signaling results in heart overgrowth and reduced cardiac output in Drosophila. Genetics 176:1609-1624.

         Bergter, A., Hunnekuhl, V., Schniederjans, M. and Paululat, A. (2007) Evolutionary aspects of pattern formation during clitellate muscle formation. Evolution & Development 9(6): 602-617.

         Popichenko, D., Sellin, J., Bartkuhn, M. and Paululat, A. (2007) Hand is a direct target of the forkhead transcription factor Biniou. BMC Developmental Biology 7: 49 (p. 1-9).

         Bergter, A. and Paululat, A. (2007) Pattern of Body-wall Muscle Differentiation during Embryonic  Development of the Oligochaete Enchytraeus coronatus  (Annelida). Journal of Morphology 268: 537-549.

         Albrecht, S., Wang, S., Holz, A., Bergter,  A. and Paululat, A. (2006) The ADAM metalloprotease Kuzbanian  is essential for heart formation in Drosophila melanogaster. Mechanisms of Development 123 (5): 372-387.

         Sellin, S., Albrecht, S., Kölsch, V.  and Paululat, A. (2006) Dynamics of heart differentiation,  visualized utilizing enhancer elements of the Drosophila  melanogaster bHLH transcription factor Hand. Gene Expression Patterns 6(4): 360-375.

         Popichenko, D. and Paululat, A. (2004) Cell fate decisions in the Drosophila dorsal vessel depend  on the multiadapter protein Inscuteable. Genesis 40: 218-222.

        Bergter,  A., Brand, C., Beck, L. and Paululat, A. (2004)The  embryonic development of the oligochaete Enchytraeus coronatus:  a SEM and histological study of embryogenesis from one-cell stage  to hatching. Journal of Morphology 261: 26-42.

         Brand, C., Bergter, A. and Paululat, A. (2003) Cloning of a twist orthologue from Enchytraeus coronatus (Annelida. Oligochaeta). DNA Sequence 14(1): 25-31.

         Kölsch, V. and Paululat, A. (2002) The highly conserved cardiogenic bHLH factor Hand is specifically expressed in circular viszeral muscle progenitor cells and in all cell types of the dorsal vessel during Drosophila embryogenesis. Dev. Genes & Evol. 212: 473-485.

         Lier, S. and Paululat, A. (2002) Characterization of the Drosophila proteasome regulatory particle subunit Rpn6 and its  interaction with signalosome subunit Alien/CSN2. Gene 298: 109-119.

         Rau, A., Buttgereit, D., Holz, A., Fetter, R., Doberstein, S.K., Paululat, A., Staudt, N., Skeath, J., Michelson, A.M. and Renkawitz-Pohl, R. (2001) During Drosophila muscle development rolling pebbles (rols) is required in muscle precursor cells to recruit further myoblasts for fusion. Development 128 (24) 5061-5073.

         Sievert, V., Kuhn, S., Paululat, A. and Traut, W. (2000) Sequence conservation and expression of the Sex-lethal homologue in the fly Megaselia scalaris. Genome 43 (2): 382-390.

         Grzeschik, N., Breuer, S., Renkawitz-Pohl, R. and Paululat, A. (1999) Molecular characterization of a point mutation in the Drosophila inscuteable gene. D.I.S.  82: 27-29.

         Paululat, A. Breuer, S. and Renkawitz-Pohl, R. (1999) Determination and development of the larval muscle pattern in Drosophila melanogaster. Cell & Tiss. Res. 296, 151-160.

         Dressel, U., Thormeyer, D., Altincicek, B., Paululat, A., Eggert, M., Schneider, S., Tenbaum, S. P., Renkawitz, R. and Baniahmad, A. (1999) Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol. Cell. Biol. 19, 3383-3394.

         Paululat, A., Holz, A. and Renkawitz-Pohl, R. (1999) Essential genes for myoblast fusion in Drosophila embryogenesis.  Mech. Dev. 83, 17-26.

         Hassan, B.A., Prokopenko, S.N., Breuer, S., Zhang, B., Paululat, A. and Bellen, H. (1998) skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle formation, but not for neurotransmitter release. Genetics 150, 1527-1537.

         Knirr, S., Breuer, S., Paululat, A. and Renkawitz-Pohl, R. (1997) Somatic mesoderm differentiation, and the development of a subset of pericardial cells depend on the not enough muscle (nem) locus, which contains the inscuteable gene and the intron located gene skittles. Mech. Dev. 67, 69-81.

         Paululat, A., Goubeaud, A., Damm, C., Knirr, S., Burchard, S. and Renkawitz-Pohl, R. (1997) The mesodermal expression of rolling stone (rost) is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein. J. Cell Biol.138, 337-348.

         Goubeaud, A., Knirr, S., Renkawitz-Pohl, R. and Paululat, A. (1996) The Drosophila gene alien is expressed in the muscle attachment sites during embryogenesis and encodes a protein highly conserved between plants, Drosophila and vertebrates. Mech. Dev. 57, 59-68.

         Paululat, A. (1996) try29F (Drosophila trypsin-related protein), a new member of the Drosphila trypsin-like protease gene family, is specifically expressed in the posterior midgut. Gene 172, 245-247.

         Buttgereit, D., Paululat, A. and Renkawitz-Pohl, R. (1996) Muscle development and attachment to the epidermis is accompanied by expression of ß3 and ß1 tubulin isotypes, respectively. Int. J. Dev. Biol. 40, 189-196.

         Burchard, S., Paululat, A., Hinz, U. and Renkawitz-Pohl, R. (1995) The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern. J. Cell Sci. 108, 1443-1454.

         Paululat, A., Burchard, S. and Renkawitz-Pohl, R. (1995) Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila. Development 121, 2611-2620.


Achim Paululat